The show begins with Michael Scofield, a genius engineer who gets himself incarcerated in Fox River State Penitentiary to break out his brother Lincoln, who is on death row for a crime he did not commit. Michael gets a tattoo of the prison's layout on his body and starts digging an escape route. The series explores themes of loyalty, family, and the corrupt prison system.

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The beauty of using 123movies for Prison Break specifically was the "binge-ability." Unlike network TV that forced you to wait a week for the next cliffhanger (e.g., "Is Sara dead?"), 123movies let you watch episode 210 ("Rendezvous") immediately after episode 209.