Chip Main Memory With The Contents Are In Disagreement Ch341a — Top [2021]

Start with the software speed reduction. If that fails, move to the 3.3V voltage mod. For stubborn Top chips, add the 10k pull-up resistor. Only as a last resort should you desolder.

If you are using an IC test clip (like a Pomona or standard SOP8 clip) to program the chip directly on the motherboard without desoldering, bad contact is highly likely. Start with the software speed reduction

Believe it or not, 20% of "disagreement" errors are simply bad physical contact. Start with the software speed reduction

Are you trying to read/write the chip ?