) or a Grignard reagent (though less common in standard A-Level).
by James M. Coxon. This book not only provides model answers but also “discusses, in detail, the reasons why particular strategies are chosen, and why, in given circumstances, alternative methods or routes may or may not be appropriate.”
to an asymmetric alkene will follow Markovnikov's rule, yielding the secondary or tertiary bromoalkane as the major product. If your target requires the primary bromoalkane, a different synthetic route is necessary. Core Reaction Pathways You Must Memorize
If a molecule has both an amine and an alcohol, and you need to react the alcohol – protect the amine with Boc2O or CbzCl . Chemsheets problems rarely show this, but advanced answer keys include it.
) or a Grignard reagent (though less common in standard A-Level).
by James M. Coxon. This book not only provides model answers but also “discusses, in detail, the reasons why particular strategies are chosen, and why, in given circumstances, alternative methods or routes may or may not be appropriate.”
to an asymmetric alkene will follow Markovnikov's rule, yielding the secondary or tertiary bromoalkane as the major product. If your target requires the primary bromoalkane, a different synthetic route is necessary. Core Reaction Pathways You Must Memorize
If a molecule has both an amine and an alcohol, and you need to react the alcohol – protect the amine with Boc2O or CbzCl . Chemsheets problems rarely show this, but advanced answer keys include it.
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