For lupus patients, low cortisol is a disaster. Without sufficient cortisol, regulatory T cells (which prevent autoimmunity) fail to function. The result? Chronic, low-grade systemic inflammation that smolders for years before erupting into full-blown lupus.
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: Early trauma can lead to chemical "marks" on DNA that alter how genes related to the immune system are expressed, potentially "switching on" a genetic predisposition for lupus. 3. Broad Health Implications For lupus patients, low cortisol is a disaster